Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 13/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.42 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8292205 | 0.82 | UTS2R (0.42) | UTS2ROPRK1CYP3A4CYP2D6HCRTR1 | |
| Hydrochloric Acid SCHEMBL8593239 | 0.75 | TACR2 (0.49) | UTS2RCYP3A4CYP2D6TACR2TACR1 | |
| SCHEMBL7956616 | 0.75 | TACR2 (0.44) | UTS2RCYP3A4HCRTR1HCRTR2TACR2 | |
| SCHEMBL8589466 | 0.75 | TACR1 (0.46) | UTS2ROPRK1CYP3A4CYP2D6TACR2 | |
| SCHEMBL8143557 | 0.74 | ALDH1A1 (0.46) | UTS2ROPRK1CYP3A4CYP2D6TACR2 | |
| Hydrochloric Acid SCHEMBL6543507 | 0.74 | ALDH1A1 (0.45) | UTS2ROPRK1CYP3A4CYP2D6TACR2 | |
| SCHEMBL5636471 | 0.70 | CHRNB2 (0.49) | — | |
| SCHEMBL5637493 | 0.70 | CHRNB2 (0.49) | — | |
| SCHEMBL8292203 | 0.69 | UTS2R (0.41) | UTS2ROPRK1CYP3A4CYP2D6HCRTR1 | |
| SCHEMBL8593208 | 0.69 | UTS2R (0.39) | UTS2ROPRK1CYP3A4CYP2D6HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770735-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1998-06-23 | — | — | US | claimed |
| EP-0512901-B1 | Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1999-06-23 | — | — | EP | disclosed |
| US-5770735-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1998-06-23 | — | — | US | disclosed |
| US-5625060-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present | Sanofi, Elf (FR) | 1997-04-29 | — | — | US | disclosed |
| US-5340822-A | Substance P, neurokinin antagonists | ELF SANOFI (FR) | 1994-08-23 | — | — | US | disclosed |
| EP-0512901-A1 | Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-11-11 | — | — | EP | disclosed |