Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8290247 | 0.85 | ALDH1A1 (0.43) | ALDH1A1RECQLPOLBGAALMNA | |
| SCHEMBL19265679 | 0.82 | ALDH1A1 (0.62) | ALDH1A1RECQLPOLBGAALMNA | |
| SCHEMBL27582818 | 0.78 | MEN1 (0.54) | ALDH1A1RECQLPOLBGAALMNA | |
| SCHEMBL27799842 | 0.75 | LMNA (0.68) | ALDH1A1POLBGAALMNATSHR | |
| SCHEMBL30218661 | 0.74 | POLB (0.54) | ALDH1A1POLBLMNATSHRNPC1 | |
| SCHEMBL10064150 | 0.71 | ALDH1A1 (0.60) | ALDH1A1RECQLPOLBGAALMNA | |
| SCHEMBL10765171 | 0.71 | MAPT (0.69) | ALDH1A1RECQLPOLBGAALMNA | |
| SCHEMBL9695968 | 0.69 | SMN1; SMN2 (0.56) | ALDH1A1RECQLPOLBGAALMNA | |
| SCHEMBL1374759 | 0.68 | NPC1 (0.71) | ALDH1A1POLBGAALMNAL3MBTL1 | |
| SCHEMBL10670593 | 0.68 | LMNA (0.66) | RECQLPOLBGAALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042497-A2 | BENZIMIDAZOLES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |