Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 3/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18239176 | 0.71 | CTSD (0.37) | CYP2D6CYP2C19MAPTRENCTSD | |
| SCHEMBL2499332 | 0.70 | RNPEP (0.31) | MMP1 | |
| SCHEMBL6716688 | 0.69 | ANPEP (0.50) | CYP2D6CYP2C19MAPT | |
| SCHEMBL1482053 | 0.69 | RNPEP (0.31) | MMP1MMP3 | |
| SCHEMBL5634723 | 0.69 | CTSS (0.33) | — | |
| SCHEMBL830163 | 0.68 | SLC7A5 (0.45) | CYP2D6CYP2C19MAPTCTSD | |
| SCHEMBL836923 | 0.68 | SLC7A5 (0.45) | CYP2D6CYP2C19MAPTCTSD | |
| SCHEMBL3774071 | 0.68 | MAPT (0.44) | CYP2D6CYP2C19MAPT | |
| SCHEMBL3774073 | 0.68 | MAPT (0.44) | CYP2D6CYP2C19MAPT | |
| SCHEMBL16371588 | 0.68 | FPR2 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143375-B2 | Aziridine aldehydes, aziridine-conjugated amino derivatives, aziridine-conjugated biomolecules and processes for their preparation | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-03-27 | — | — | US | disclosed |