Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 17/20 | 0.51 |
| ▸ | RXRG | P48443 | 10/20 | 0.40 |
| ▸ | RXRB | P28702 | 9/20 | 0.40 |
| ▸ | RARA | P10276 | 5/20 | 0.40 |
| ▸ | RARB | P10826 | 4/20 | 0.40 |
| ▸ | RARG | P13631 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15348324 | 0.87 | RXRA (0.51) | RXRARXRGRXRBRARARARB | |
| SCHEMBL22923355 | 0.83 | RXRA (0.39) | RXRARXRGRXRBRARARARB | |
| SCHEMBL4654263 | 0.81 | RXRA (0.37) | RXRARXRGRXRBADORA3CHRM1 | |
| SCHEMBL1496270 | 0.81 | MAPT (0.38) | RXRARXRGRXRB | |
| SCHEMBL5490803 | 0.80 | RXRA (0.49) | RXRARXRGRXRBRARARARB | |
| SCHEMBL15362744 | 0.80 | RXRA (0.46) | RXRARXRGRXRBRARARARB | |
| SCHEMBL7622765 | 0.79 | RXRA (0.48) | RXRARXRGRXRBRARARARB | |
| SCHEMBL26607136 | 0.78 | RXRA (0.46) | RXRARXRGRXRBMEN1KMT2A | |
| SCHEMBL30573101 | 0.78 | RXRA (0.46) | RXRARXRGRXRBMEN1KMT2A | |
| SCHEMBL6086554 | 0.78 | RXRA (0.46) | RXRARXRGRXRBTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9203112-B2 | Redox shuttles having an aromatic ring fused to a 1,1,4,4-tetrasubstituted cyclohexane ring | UCHICAGO ARGONNE, LLC (US) | 2015-12-01 | — | — | US | disclosed |
| US-20130288137-A1 | REDOX SHUTTLES HAVING AN AROMATIC RING FUSED TO A 1,1,4,4-TETRASUBSTITUTED CYCLOHEXANE RING | UCHICAGO ARGONNE, LLC | 2013-10-31 | — | — | US | disclosed |
| US-7923579-B2 | Tricyclic hydroxamate and benzamide derivatives, compositions and methods | EXONHIT THERAPEUTICS S.A. (FR) | 2011-04-12 | — | — | US | disclosed |
| EP-1692097-B1 | TRICYCLIC HYDROXAMATE AND BENZAMIDE DERIVATIVES, COMPOSITIONS AND METHODS | EXONHIT THERAPEUTICS SA (FR) | 2009-09-02 | — | — | EP | disclosed |
| US-20070129368-A1 | Tricyclic hydroxamate and benzamide derivatives, compositions and methods | EXONHIT THERAPEUTICS S.A. (FR) | 2007-06-07 | — | — | US | disclosed |
| WO-2005058803-A1 | TRICYCLIC HYDROXAMATE AND BENZAMIDE DERIVATIVES, COMPOSITIONS AND METHODS | EXONHIT THERAPEUTICS SA (FR) | 2005-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130288137-A1 | REDOX SHUTTLES HAVING AN AROMATIC RING FUSED TO A 1,1,4,4-TETRASUBSTITUTED CYCLOHEXANE RING | SLC25A21, SLC25A1, SLC25A11 | RXRA 2860/4885RXRG 3052/4885RXRB 3375/4885 |
| US-20070129368-A1 | Tricyclic hydroxamate and benzamide derivatives, compositions and methods | HDAC5, HDAC1, HDAC2 | RXRA 1796/4885RXRG 1653/4885RXRB 2026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.