Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2799190 | 1.00 | MEN1 (0.41) | MEN1KMT2ASMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL14390564 | 0.83 | SMN1; SMN2 (0.42) | MEN1KMT2ASMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL13232748 | 0.83 | ALDH1A1 (0.42) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2797694 | 0.83 | ALDH1A1 (0.42) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8293070 | 0.83 | ALDH1A1 (0.42) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8294637 | 0.79 | LMNA (0.45) | MEN1KMT2ASMN1; SMN2ALDH1A1AR | |
| SCHEMBL2800995 | 0.79 | LMNA (0.45) | MEN1KMT2ASMN1; SMN2ALDH1A1AR | |
| SCHEMBL1647150 | 0.73 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL7900406 | 0.72 | CA12 (0.37) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4711162 | 0.72 | ALDH1A1 (0.42) | MEN1KMT2AALDH1A1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168112-A1 | 2-Substituted and 4-substituted aryl nitrone compounds | RENOVIS, INC. | 2010-07-01 | — | — | US | disclosed |
| WO-2005016272-A2 | ARYL, HETEROAROMATIC AND BICYCLIC ARYL NITRONE COMPOUNDS, PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS | RENOVIS, INC. (US) | 2005-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168112-A1 | 2-Substituted and 4-substituted aryl nitrone compounds | CXCR2, CCL5, CCL2 | MEN1 4882/4885KMT2A 4071/4885SMN1; SMN2 1311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.