Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | PTAFR | P25105 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8294741 | 0.91 | HDAC1 (0.49) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8294740 | 0.78 | HDAC1 (0.56) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8272091 | 0.76 | HDAC1 (0.67) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8293929 | 0.76 | HDAC6 (0.60) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8293934 | 0.72 | ALOX12 (0.43) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL26428761 | 0.71 | NAAA (0.65) | HDAC3 | |
| SCHEMBL1365042 | 0.71 | HDAC1 (0.68) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL1364875 | 0.69 | HDAC1 (0.66) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL13906604 | 0.67 | — | — | |
| SCHEMBL12905119 | 0.66 | HDAC1 (0.41) | HDAC1HDAC8HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007091-A2 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2005-01-27 | — | — | WO | disclosed |