Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 9/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.37 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3367520 | 0.90 | CRHR1 (0.43) | CRHR1CNR1GALR3CYP1A2CYP3A4 | |
| SCHEMBL3368073 | 0.89 | CRHR1 (0.41) | CRHR1CNR1BDKRB2GALR3CYP1A2 | |
| SCHEMBL3364556 | 0.85 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL3364574 | 0.83 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL3366785 | 0.82 | CRHR1 (0.43) | CRHR1CNR1F2RL3 | |
| SCHEMBL3839128 | 0.81 | CRHR1 (0.51) | CRHR1 | |
| SCHEMBL3366146 | 0.81 | CRHR1 (0.43) | CRHR1CNR1SMN1; SMN2CHRM3 | |
| SCHEMBL6024733 | 0.81 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL3365373 | 0.80 | CRHR1 (0.46) | CRHR1CNR1 | |
| SCHEMBL3364478 | 0.80 | CRHR1 (0.49) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365211-B2 | Heterocyclic GABAA subtype selective receptor modulators | ROCHE PALO ALTO LLC (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365211-B2 | Heterocyclic GABAA subtype selective receptor modulators | ROCHE PALO ALTO LLC (US) | 2008-04-29 | — | — | US | disclosed |
| WO-2005016892-A1 | GABANERGIC MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-02-24 | — | — | WO | disclosed |