Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.61 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10438586 | 0.81 | DRD2 (0.71) | DRD2ADRA1DADRA1AADRA1BDRD3 | |
| SCHEMBL6934502 | 0.81 | DRD2 (0.66) | DRD2ADRA1DADRA1AADRA1BDRD3 | |
| SCHEMBL8363314 | 0.80 | DRD2 (0.77) | DRD2ADRA1DADRA1AADRA1BDRD3 | |
| SCHEMBL6930794 | 0.78 | DRD2 (0.66) | DRD2ADRA1DADRA1AADRA1BDRD3 | |
| SCHEMBL6526368 | 0.78 | DRD2 (0.85) | DRD2ADRA1DADRA1AADRA1BDRD3 | |
| SCHEMBL31060769 | 0.77 | DRD2 (1.00) | DRD2ADRA1DADRA1AADRA1BDRD3 | |
| SCHEMBL3261221 | 0.77 | DRD2 (1.00) | DRD2ADRA1DADRA1AADRA1BDRD3 | |
| SCHEMBL8577935 | 0.76 | DRD2 (0.72) | DRD2ADRA1DADRA1AADRA1BDRD3 | |
| SCHEMBL7600435 | 0.76 | DRD2 (0.74) | DRD2DRD3DRD4 | |
| SCHEMBL5442134 | 0.76 | ADRA1D (1.00) | DRD2ADRA1DADRA1AADRA1BDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625514-B1 | 2-Amino-pyrazin-5-carboxamid derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1999-08-25 | — | — | EP | disclosed |
| US-5420130-A | Adrenergic blocking agents | SYNTHELABO (FR) | 1995-05-30 | — | — | US | disclosed |
| EP-0625514-A1 | 2-Amino-pyrazin-5-carboxamid derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1994-11-23 | — | — | EP | disclosed |
| US-5164397-A | Hypotensive | SYNTHELABO (FR) | 1992-11-17 | — | — | US | disclosed |
| EP-0435749-A1 | Derivatives of 2-aminopyrimidine-4-carboxamide, their preparation and therapeutic use | SYNTHELABO (FR) | 1991-07-03 | — | — | EP | disclosed |