Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037044 | 0.83 | TDP1 (0.65) | TDP1RAB9AENPP2TSHRALDH1A1 | |
| SCHEMBL4478554 | 0.74 | ALDH1A1 (0.57) | TDP1RAB9ATSHRALDH1A1MAPT | |
| SCHEMBL1779695 | 0.74 | RAB9A (0.68) | TDP1RAB9ATSHRALDH1A1MAPT | |
| SCHEMBL1598783 | 0.73 | ALDH1A1 (0.56) | TDP1RAB9ATSHRALDH1A1POLB | |
| SCHEMBL10277241 | 0.73 | RAB9A (0.53) | TDP1RAB9ATSHRALDH1A1MAPT | |
| SCHEMBL5190384 | 0.73 | RAB9A (0.53) | TDP1RAB9ATSHRALDH1A1MAPT | |
| SCHEMBL4465081 | 0.72 | MAPT (0.57) | TDP1RAB9ATSHRALDH1A1POLB | |
| SCHEMBL1467717 | 0.71 | TDP1 (0.51) | TDP1ALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL7681730 | 0.70 | TDP1 (0.61) | TDP1TSHRALDH1A1HSD17B10MEN1 | |
| SCHEMBL20037332 | 0.69 | TSHR (0.56) | TDP1RAB9AENPP2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620214-B1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | LILLY CO ELI (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5578634-A | SEPTIC SHOCK TREATMENT | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0620214-A1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |