Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.75 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.70 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.70 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.70 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.70 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.70 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.70 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | NAMPT | P43490 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16248437 | 0.91 | LMNA (0.70) | NAAAHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL9492235 | 0.91 | HDAC1 (0.82) | NAAAHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL9452844 | 0.91 | HDAC1 (0.82) | NAAAHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL9489804 | 0.91 | HDAC1 (0.82) | NAAAHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL9188890 | 0.91 | HDAC1 (0.82) | NAAAHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL9492328 | 0.91 | HDAC1 (0.82) | NAAAHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL7460068 | 0.91 | HDAC1 (0.82) | NAAAHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL9489756 | 0.91 | HDAC1 (0.82) | NAAAHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL20734829 | 0.91 | HDAC1 (0.82) | NAAAHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL8779817 | 0.89 | HDAC1 (0.79) | NAAAHDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007091-A2 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2005-01-27 | — | — | WO | disclosed |