Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 13/20 | 0.58 |
| ▸ | CTSL | P07711 | 8/20 | 0.53 |
| ▸ | CTSB | P07858 | 6/20 | 0.53 |
| ▸ | CTSF | Q9UBX1 | 5/20 | 0.53 |
| ▸ | CTSV | O60911 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5379002 | 0.88 | CTSK (0.73) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL8293279 | 0.84 | CTSK (0.78) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL8295817 | 0.84 | CTSK (0.57) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL14350242 | 0.82 | CTSK (0.66) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL14350320 | 0.82 | CTSK (0.66) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL11981467 | 0.82 | CTSK (0.61) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL8433997 | 0.82 | CTSK (0.61) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL8294938 | 0.81 | CTSK (0.62) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL8296667 | 0.81 | CTSK (0.60) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL8295393 | 0.81 | CTSK (0.58) | CTSKCTSLCTSBCTSFCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312353-B2 | Cathespin cysteine protease inhibitors | MERCK FROST CANADA & CO. (CA) | 2007-12-25 | — | — | US | disclosed |
| WO-2005019161-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2005-03-03 | — | — | WO | disclosed |