Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.61 |
| ▸ | CTSL | P07711 | 7/20 | 0.58 |
| ▸ | CTSB | P07858 | 5/20 | 0.58 |
| ▸ | CTSF | Q9UBX1 | 4/20 | 0.58 |
| ▸ | CTSV | O60911 | 1/20 | 0.58 |
| ▸ | CTSS | P25774 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11981467 | 1.00 | CTSK (0.61) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL11981450 | 0.90 | CTSK (0.76) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL11981448 | 0.90 | CTSK (0.76) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL14350320 | 0.88 | CTSK (0.66) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL14350242 | 0.88 | CTSK (0.66) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL8117533 | 0.87 | CTSK (0.76) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL8433829 | 0.87 | CTSK (0.65) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL8296667 | 0.87 | CTSK (0.60) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL8294938 | 0.87 | CTSK (0.62) | CTSKCTSLCTSBCTSFCTSV | |
| SCHEMBL14494210 | 0.87 | CTSK (0.65) | CTSKCTSLCTSBCTSFCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407959-B2 | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA & CO. (CA) | 2008-08-05 | — | — | US | disclosed |
| US-20060111440-A1 | Cathepsin cysteine protease inhibitors | MERCK CANADA INC. (CA) | 2006-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111440-A1 | Cathepsin cysteine protease inhibitors | CTSB, CTSS, CTSZ | CTSK 4/4885CTSL 8/4885CTSB 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.