Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 9/20 | 0.59 |
| ▸ | TACR2 | P21452 | 2/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RNF4 | P78317 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8297639 | 0.89 | ROCK2 (0.54) | LTA4HFPR2ROCK2ROCK1 | |
| SCHEMBL8295559 | 0.89 | ROCK2 (0.54) | LTA4HFPR2ROCK2ROCK1 | |
| SCHEMBL14519537 | 0.89 | ROCK2 (0.54) | LTA4HFPR2ROCK2ROCK1 | |
| SCHEMBL5406573 | 0.85 | MAPK1 (0.52) | LTA4HNPY5RFPR2MAPK1CYP2C9 | |
| SCHEMBL5406565 | 0.85 | MAPK1 (0.52) | LTA4HNPY5RFPR2MAPK1CYP2C9 | |
| SCHEMBL14519547 | 0.85 | TACR2 (0.54) | TACR2 | |
| SCHEMBL8296134 | 0.85 | TACR2 (0.54) | TACR2 | |
| SCHEMBL5406639 | 0.85 | LTA4H (0.44) | LTA4HTACR2NPY5RFPR2MAPK1 | |
| SCHEMBL5406645 | 0.85 | LTA4H (0.44) | LTA4HTACR2NPY5RFPR2MAPK1 | |
| SCHEMBL14519538 | 0.82 | ROCK2 (0.52) | FPR2ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202269-B2 | GlyT2 modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-10 | — | — | US | disclosed |
| US-7202269-B2 | GlyT2 modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-10 | — | — | US | disclosed |
| WO-2005044810-A1 | GLYT2 MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-05-19 | — | — | WO | disclosed |