Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.54 |
| ▸ | MME | P08473 | 2/20 | 0.50 |
| ▸ | CASR | P41180 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 8/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14519537 | 1.00 | ROCK2 (0.54) | ROCK2ROCK1MMECASRFPR2 | |
| SCHEMBL8295559 | 1.00 | ROCK2 (0.54) | ROCK2ROCK1MMECASRFPR2 | |
| SCHEMBL14519538 | 0.94 | ROCK2 (0.52) | ROCK2ROCK1MMECASRFPR2 | |
| SCHEMBL8296808 | 0.89 | LTA4H (0.59) | ROCK2ROCK1FPR2LTA4H | |
| SCHEMBL8297668 | 0.88 | ROCK2 (0.53) | ROCK2ROCK1MMECASRFPR2 | |
| SCHEMBL8297619 | 0.87 | ROCK2 (0.52) | ROCK2ROCK1MMECASRFPR2 | |
| SCHEMBL14543614 | 0.86 | ROCK2 (0.51) | ROCK2ROCK1MMECASRFPR2 | |
| SCHEMBL8295543 | 0.86 | ROCK2 (0.51) | ROCK2ROCK1MMECASRFPR2 | |
| SCHEMBL14519532 | 0.85 | ROCK2 (0.50) | ROCK2ROCK1MMECASRFPR2 | |
| SCHEMBL8296137 | 0.85 | ROCK2 (0.49) | ROCK2ROCK1MMECASRFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005044810-A1 | GLYT2 MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-05-19 | — | — | WO | disclosed |