Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15520897 | 0.97 | CYP2A6 (0.43) | L3MBTL1MTNR1AMTNR1BHPGDCYP2A6 | |
| SCHEMBL15520895 | 0.97 | CYP2A6 (0.43) | L3MBTL1MTNR1AMTNR1BHPGDCYP2A6 | |
| SCHEMBL22096928 | 0.82 | LMNA (0.49) | L3MBTL1CYP2A6MAOAMAOBALDH1A1 | |
| SCHEMBL11120372 | 0.79 | MTNR1A (0.46) | L3MBTL1MTNR1AMTNR1BHPGDALDH1A1 | |
| SCHEMBL5785923 | 0.78 | MAOB (0.50) | HPGDMAOAMAOBALDH1A1LMNA | |
| SCHEMBL5785926 | 0.78 | MAOB (0.50) | HPGDMAOAMAOBALDH1A1LMNA | |
| SCHEMBL5787405 | 0.75 | KDM4E (0.45) | L3MBTL1ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL5787402 | 0.75 | KDM4E (0.45) | L3MBTL1ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL2286745 | 0.75 | NQO2 (0.46) | L3MBTL1MTNR1AMTNR1BALDH1A1MAPT | |
| SCHEMBL2286741 | 0.75 | NQO2 (0.46) | L3MBTL1MTNR1AMTNR1BALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143260-B2 | Tricyclic amine compound | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2012-03-27 | — | — | US | disclosed |
| US-20110288299-A1 | TRICYCLIC AMINE COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-11-24 | — | — | US | disclosed |
| US-20110213157-A1 | TRICYCLIC AMIDE COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110213157-A1 | TRICYCLIC AMIDE COMPOUND | RXRA, RXRB, RXRG | L3MBTL1 4033/4885MTNR1A 40/4885MTNR1B 34/4885 |
| US-20110288299-A1 | TRICYCLIC AMINE COMPOUND | RXRA, RXRB, NR2C2 | L3MBTL1 3865/4885MTNR1A 29/4885MTNR1B 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.