Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | ESR1 | P03372 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4624103 | 0.85 | KDM4E (0.50) | KMT2AMAPTESR1MEN1POLB | |
| SCHEMBL8297749 | 0.84 | MAPT (0.49) | KMT2AMAPTESR1MEN1POLB | |
| SCHEMBL8297882 | 0.84 | HPGD (0.46) | KMT2AMAPTESR1MEN1POLB | |
| SCHEMBL30721723 | 0.80 | HSD17B10 (0.59) | KMT2AMAPTMEN1POLBALDH1A1 | |
| SCHEMBL5700024 | 0.80 | PTK2B (0.59) | KMT2AMAPTMEN1ALDH1A1HPGD | |
| SCHEMBL8299564 | 0.74 | MAPT (0.35) | KMT2AMAPTESR1MEN1POLB | |
| SCHEMBL8298515 | 0.72 | KMT2A (0.47) | KMT2AMAPTESR1MEN1POLB | |
| SCHEMBL129359 | 0.71 | TSHR (0.59) | KMT2AMAPTMEN1POLBALDH1A1 | |
| SCHEMBL29402736 | 0.71 | TSHR (0.59) | KMT2AMAPTMEN1POLBALDH1A1 | |
| SCHEMBL10434144 | 0.71 | MAPT (0.61) | KMT2AMAPTMEN1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005041904-A2 | INHIBITORS OF CORONAVIRUS PROTEASE AND METHODS OF USE THEREOF | FULCRUM PHARMACEUTICALS, INC. (US) | 2005-05-12 | — | — | WO | disclosed |