Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.37 |
| ▸ | ITGB7 | P26010 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8298330 | 0.89 | ITGB1 (0.39) | PRMT5ITGB1ITGA4ITGB7P2RX7 | |
| SCHEMBL8297146 | 0.88 | ITGB1 (0.48) | CHRM1PRMT5ITGB1ITGA4ITGB7 | |
| SCHEMBL14603026 | 0.81 | ITGA4 (0.57) | ITGB1ITGA4ITGB7ALDH1A1GAA | |
| SCHEMBL8299842 | 0.71 | ITGB1 (0.43) | ITGB1ITGA4ITGB7KCNK3P2RX7 | |
| SCHEMBL8299843 | 0.67 | SMN1; SMN2 (0.48) | ITGB1ITGA4ITGB7SMN1; SMN2KDM4E | |
| SCHEMBL8297130 | 0.66 | ITGA4 (0.57) | ITGB1ITGA4ITGB7USP2CHRM2 | |
| SCHEMBL8297127 | 0.66 | ITGA4 (0.57) | ITGB1ITGA4ITGB7USP2CHRM2 | |
| SCHEMBL8297110 | 0.66 | ITGB1 (0.59) | ITGB1ITGA4ITGB7ALDH1A1GAA | |
| SCHEMBL14603022 | 0.65 | ITGB1 (0.60) | ITGB1ITGA4ITGB7USP2CHRM2 | |
| SCHEMBL14603028 | 0.65 | ITGB1 (0.57) | ITGB1ITGA4ITGB7USP2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004103967-A2 | THIOCARBAMATE INHIBITORS OF ALPHA-4 INTEGRINS | GENENTECH, INC. (US) | 2004-12-02 | — | — | WO | disclosed |