Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ADH1B | P00325 | 1/20 | 0.33 |
| ▸ | ADH1C | P00326 | 1/20 | 0.33 |
| ▸ | ADH1A | P07327 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29335384 | 0.95 | KDM4E (0.47) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL21534451 | 0.81 | C3AR1 (0.36) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL11887166 | 0.80 | KDM4E (0.56) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL17951698 | 0.80 | ADH1B (0.53) | SIRT6SIRT1DPP7ZDHHC7ADH1B | |
| SCHEMBL10408291 | 0.80 | KDM4E (0.56) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL14932592 | 0.80 | KDM4E (0.56) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL14932573 | 0.80 | KDM4E (0.56) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL17210488 | 0.79 | GSR (0.42) | FOLH1PAOXSIRT6SIRT1DPP7 | |
| SCHEMBL27312128 | 0.77 | SMN1; SMN2 (0.43) | KDM4EMAPK1HIF1AFOLH1PAOX | |
| SCHEMBL20235708 | 0.77 | KDM4E (0.52) | KDM4EMAPK1HIF1AFOLH1PAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005000244-A2 | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS | ELAN PHARMACEUTICALS, INC. (US) | 2005-01-06 | — | — | WO | disclosed |