Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C3AR1 | Q16581 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.31 |
| ▸ | OTC | P00480 | 1/20 | 0.30 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.30 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29335384 | 0.86 | KDM4E (0.47) | DPP7SIRT5SIRT6SIRT1KDM4E | |
| SCHEMBL17326511 | 0.82 | SIRT5 (0.34) | C3AR1SIRT5SIRT6SIRT1KISS1R | |
| SCHEMBL8298580 | 0.81 | KDM4E (0.50) | DPP7SIRT5SIRT6SIRT1ALB | |
| SCHEMBL15315075 | 0.81 | C3AR1 (0.38) | C3AR1DPP7SIRT5SIRT6SIRT1 | |
| SCHEMBL15691795 | 0.81 | C3AR1 (0.38) | C3AR1DPP7SIRT5SIRT6SIRT1 | |
| SCHEMBL10441955 | 0.81 | C3AR1 (0.38) | C3AR1DPP7SIRT5SIRT6SIRT1 | |
| SCHEMBL24135883 | 0.80 | C3AR1 (0.41) | C3AR1DPP7DDAH1CTDSP1FOLH1 | |
| SCHEMBL21152967 | 0.78 | C3AR1 (0.36) | C3AR1DPP7SIRT5SIRT6SIRT1 | |
| SCHEMBL24420994 | 0.78 | C3AR1 (0.36) | C3AR1DPP7SIRT5SIRT6SIRT1 | |
| SCHEMBL17210488 | 0.77 | GSR (0.42) | DPP7SIRT6SIRT1FOLH1PAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102507-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-06-08 | — | — | WO | disclosed |
| EP-3169368-B1 | LINKERS AND THEIR APPLICATION TOWARDS ADC | MEDSHINE DISCOVERY INC (CN) | 2021-02-17 | — | — | EP | disclosed |
| US-10463749-B2 | Maytansinoid derivatives, conjugates thereof, and methods of use | REGENERON PHARMACEUTICALS, INC. (US) | 2019-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10463749-B2 | Maytansinoid derivatives, conjugates thereof, and methods of use | HNMT, SLC10A1, SLC10A2 | C3AR1 419/4885DPP7 624/4885SIRT5 2864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.