⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6905385 | 0.77 | ACHE (0.41) | — | |
| SCHEMBL874081 | 0.76 | CES2 (0.46) | — | |
| SCHEMBL13357232 | 0.72 | — | — | |
| SCHEMBL15933211 | 0.72 | TAAR1 (0.38) | — | |
| SCHEMBL471457 | 0.69 | — | — | |
| SCHEMBL13863272 | 0.69 | CES2 (0.42) | — | |
| SCHEMBL13863241 | 0.69 | CA9 (0.48) | — | |
| SCHEMBL13107429 | 0.69 | CES2 (0.43) | — | |
| SCHEMBL45406 | 0.67 | — | — | |
| SCHEMBL29352330 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11384048-B2 | Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application | GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD. (CN) | 2022-07-12 | — | — | US | disclosed |
| US-20220168268-A1 | SMALL-MOLECULE INHIBITOR OF PD-1/PD-L1, PHARMACEUTICAL COMPOSITION THEREOF WITH PD-L1 ANTIBODY, AND APPLICATION OF SAME | GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD. (CN) | 2022-06-02 | — | — | US | disclosed |
| EP-3664802-B1 | BICYCLIC INHIBITORS OF HISTONE DEACETYLASE | ALKERMES INC (US) | 2022-02-23 | — | — | EP | disclosed |
| US-20210061755-A1 | AROMATIC VINYL OR AROMATIC ETHYL DERIVATIVE, PREPARATION METHOD THEREFOR, INTERMEDIATE, PHARMACEUTICAL COMPOSITION, AND APPLICATION | GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD. (CN) | 2021-03-04 | — | — | US | disclosed |
| WO-2019032528-A1 | BICYCLIC INHIBITORS OF HISTONE DEACETYLASE | RODIN THERAPEUTICS, INC (US) | 2019-02-14 | — | — | WO | disclosed |
| EP-2661433-B1 | INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) | NOVARTIS AG (CH) | 2017-08-16 | — | — | EP | disclosed |
| WO-2017097215-A1 | WNT PATHWAY INHIBITOR EMBEDDED WITH UREAS STRUCTURE | 杭州雷索药业有限公司 | 2017-06-15 | — | — | WO | disclosed |
| EP-2424532-B1 | COMPOUNDS FOR INDUCING CELLULAR APOPTOSIS | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2014093383-A1 | SUBSTITUTED 1H-PYRROLO [2,3-B] PYRIDINE AND 1H-PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS SALT INDUCIBLE KINASE 2 (SIK2) INHIBITORS | ARRIEN PHARMACEUTICALS LLC (US) | 2014-06-19 | — | — | WO | disclosed |
| WO-2013130660-A1 | AMIDES AS PIM INHIBITORS | AMGEN INC. (US) | 2013-09-06 | — | — | WO | disclosed |
| CN-101928295-A | Antibiotics containing borinic acid complexes and methods of use | ANACOR PHARMACEUTICALS INC | 2010-12-29 | — | — | CN | disclosed |
| CN-1972695-A | Treatment or prevention of skin conditions or tissue conditions in animals using boryloxypyridylmethanones | ANACOR PHARMACEUTICALS INC (US) | 2007-05-30 | — | — | CN | disclosed |
| CN-1738802-A | Antibiotics containing boronic acid complexes and methods of use | ANACOR PHARMACEUTICALS INC (US) | 2006-02-22 | — | — | CN | disclosed |
| WO-2004101565-A2 | JNK INHIBITORS | EISAI CO., LTD. (JP) | 2004-11-25 | — | — | WO | disclosed |