Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.73 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.70 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.57 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 6/20 | 0.55 |
| ▸ | HTR7 | P34969 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 5/20 | 0.54 |
| ▸ | DRD1 | P21728 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | HTR6 | P50406 | 2/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878693 | 0.85 | SLC6A4 (0.78) | DRD2SLC6A4ADRA1DADRA1BOPRM1 | |
| SCHEMBL8877539 | 0.83 | ADRA1D (0.79) | DRD2SLC6A4ADRA1DADRA1BHTR2A | |
| Hydrochloric Acid SCHEMBL7823788 | 0.82 | ADRA1D (1.00) | DRD2SLC6A4ADRA1DADRA1BOPRM1 | |
| SCHEMBL7256770 | 0.82 | ADRA1D (0.77) | DRD2SLC6A4ADRA1DADRA1BHTR2A | |
| Hydrochloric Acid SCHEMBL7867314 | 0.81 | DRD2 (0.73) | DRD2SLC6A4ADRA1DADRA1BOPRM1 | |
| Bromide SCHEMBL7870891 | 0.81 | DRD2 (0.73) | DRD2SLC6A4ADRA1DADRA1BOPRM1 | |
| SCHEMBL4475225 | 0.81 | ADRA1D (0.67) | SLC6A4ADRA1D | |
| SCHEMBL24279608 | 0.80 | DRD2 (0.77) | DRD2SLC6A4ADRA1DADRA1BOPRM1 | |
| SCHEMBL7260105 | 0.80 | ADRA1D (0.74) | DRD2SLC6A4ADRA1DADRA1BOPRM1 | |
| SCHEMBL11996944 | 0.80 | ADRA1D (0.71) | DRD2SLC6A4ADRA1DADRA1BOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0898569-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040038-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GMBH (DE) | 1997-10-30 | — | — | WO | disclosed |