Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.78 |
| ▸ | DRD2 | P14416 | 6/20 | 0.78 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.74 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.64 |
| ▸ | HTR7 | P34969 | 5/20 | 0.58 |
| ▸ | HTR2A | P28223 | 4/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.58 |
| ▸ | HTR1A | P08908 | 5/20 | 0.57 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | HTR1B | P28222 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877539 | 0.93 | ADRA1D (0.79) | SLC6A4DRD2ADRA1DADRA1BHTR7 | |
| SCHEMBL7256770 | 0.92 | ADRA1D (0.77) | SLC6A4DRD2ADRA1DADRA1BHTR7 | |
| SCHEMBL8877428 | 0.90 | OPRM1 (0.67) | SLC6A4DRD2ADRA1DHTR7HTR2A | |
| SCHEMBL8299251 | 0.85 | DRD2 (0.73) | SLC6A4DRD2ADRA1DADRA1BHTR7 | |
| Hydrochloric Acid SCHEMBL7823788 | 0.84 | ADRA1D (1.00) | SLC6A4DRD2ADRA1DADRA1BHTR7 | |
| SCHEMBL24279608 | 0.82 | DRD2 (0.77) | SLC6A4DRD2ADRA1DADRA1BHTR7 | |
| SCHEMBL7260105 | 0.82 | ADRA1D (0.74) | SLC6A4DRD2ADRA1DADRA1BHTR7 | |
| SCHEMBL11996944 | 0.82 | ADRA1D (0.71) | SLC6A4DRD2ADRA1DADRA1BHTR7 | |
| Bromide SCHEMBL7870891 | 0.82 | DRD2 (0.73) | SLC6A4DRD2ADRA1DADRA1BHTR7 | |
| Hydrochloric Acid SCHEMBL7867314 | 0.82 | DRD2 (0.73) | SLC6A4DRD2ADRA1DADRA1BHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | disclosed |
| CN-1133840-A | Indolepiperidine derivatives | MERCK PATENT GMBH (DE) | 1996-10-23 | — | — | CN | disclosed |
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |