Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 11/20 | 0.45 |
| ▸ | PPARG | P37231 | 11/20 | 0.43 |
| ▸ | ECE1 | P42892 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8298173 | 0.90 | PPARA (0.53) | PPARAPPARG | |
| SCHEMBL2406499 | 0.83 | HTT (0.45) | ECE1ALDH1A1HTT | |
| SCHEMBL5790096 | 0.83 | ESR1 (0.51) | PPARAPPARG | |
| SCHEMBL8802816 | 0.82 | TSHR (0.50) | ECE1ALDH1A1HTT | |
| SCHEMBL11073296 | 0.80 | ECE1 (0.45) | ECE1ALDH1A1HTT | |
| SCHEMBL23934473 | 0.79 | CYP2D6 (0.47) | ALDH1A1HTT | |
| SCHEMBL5788377 | 0.78 | ESR1 (0.52) | PPARAPPARG | |
| SCHEMBL2993631 | 0.77 | HTT (0.46) | ALDH1A1HTT | |
| SCHEMBL12805376 | 0.76 | MTNR1B (0.51) | PPARAPPARG | |
| SCHEMBL7956197 | 0.75 | CYP1A2 (0.53) | PPARAPPARGECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143260-B2 | Tricyclic amine compound | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2012-03-27 | — | — | US | disclosed |
| US-20110288299-A1 | TRICYCLIC AMINE COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-11-24 | — | — | US | disclosed |
| US-20110213157-A1 | TRICYCLIC AMIDE COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110213157-A1 | TRICYCLIC AMIDE COMPOUND | RXRA, RXRB, RXRG | PPARA 81/4885PPARG 11/4885ECE1 2995/4885 |
| US-20110288299-A1 | TRICYCLIC AMINE COMPOUND | RXRA, RXRB, NR2C2 | PPARA 322/4885PPARG 98/4885ECE1 2178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.