Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8802816 | 0.86 | TSHR (0.50) | ECE1HTTALDH1A1TSHRHPGD | |
| SCHEMBL9633773 | 0.84 | ALDH1A1 (0.46) | HTTALDH1A1TSHRHPGDBLM | |
| SCHEMBL829965 | 0.80 | PPARA (0.45) | ECE1HTTALDH1A1 | |
| SCHEMBL7956194 | 0.77 | CYP1A2 (0.53) | ECE1TSHRHTR2CSLC6A3 | |
| SCHEMBL7956197 | 0.77 | CYP1A2 (0.53) | ECE1TSHRHTR2CSLC6A3 | |
| SCHEMBL6476247 | 0.77 | HTT (0.49) | HTTALDH1A1TSHRBLMMEN1 | |
| SCHEMBL5623941 | 0.76 | HTR6 (0.51) | HTT | |
| SCHEMBL30644032 | 0.76 | HTT (0.48) | HTTALDH1A1TSHRBLMMEN1 | |
| SCHEMBL5285710 | 0.76 | HTT (0.48) | HTTALDH1A1TSHRBLMMEN1 | |
| SCHEMBL9567950 | 0.75 | TRPM8 (0.48) | ECE1HTTALDH1A1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4471124-A | DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1984-09-11 | — | — | US | disclosed |
| US-4442114-A | COMPLICATIONS OF DIABETES | PFIZER INC. (US) | 1984-04-10 | — | — | US | disclosed |
| US-4307108-A | DIABETES | PFIZER INC. (US) | 1981-12-22 | — | — | US | disclosed |