⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8299710 | 1.00 | — | — | |
| SCHEMBL12642061 | 0.72 | — | — | |
| SCHEMBL2350174 | 0.71 | — | — | |
| SCHEMBL8100567 | 0.70 | RIPK1 (0.36) | — | |
| SCHEMBL10901677 | 0.70 | — | — | |
| SCHEMBL28347786 | 0.70 | — | — | |
| SCHEMBL28977253 | 0.70 | FKBP1A (0.41) | — | |
| SCHEMBL28347788 | 0.70 | — | — | |
| SCHEMBL13910084 | 0.69 | CASP3 (0.31) | — | |
| SCHEMBL15012734 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833633-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0833633-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996039137-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-12-12 | — | — | WO | disclosed |