Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303965 | 0.83 | ELANE (0.35) | PDGFRACDK5TYRO3 | |
| SCHEMBL8303129 | 0.74 | NOTUM (0.40) | — | |
| SCHEMBL8631068 | 0.74 | PDGFRA (0.46) | PDGFRACDK5TYRO3 | |
| SCHEMBL8300318 | 0.71 | PDGFRA (0.46) | PDGFRACDK5TYRO3 | |
| SCHEMBL8304178 | 0.70 | ELANE (0.54) | PDGFRACDK5TYRO3 | |
| SCHEMBL10112143 | 0.70 | PDGFRA (0.65) | PDGFRACDK5TYRO3 | |
| SCHEMBL8215915 | 0.66 | SCN9A (0.36) | — | |
| SCHEMBL29139533 | 0.60 | KMT2A (0.42) | PDGFRACDK5TYRO3 | |
| SCHEMBL5103453 | 0.58 | PDGFRA (0.65) | PDGFRACDK5TYRO3 | |
| SCHEMBL30956116 | 0.56 | CES2 (0.37) | CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0701555-B1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1999-08-04 | — | — | EP | disclosed |
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |
| EP-0689539-B1 | ANTIPSYCHOTIC INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1997-12-03 | — | — | EP | disclosed |
| US-5665732-A | Indazole derivatives | MERCK, SHARP & DOHME LTD. (GB) | 1997-09-09 | — | — | US | disclosed |