Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 2/20 | 0.42 |
| ▸ | MAT2A | P31153 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.34 |
| ▸ | TSPO | P30536 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10112143 | 0.84 | PDGFRA (0.65) | PDGFRACDK5TYRO3KMOELANE | |
| SCHEMBL8631068 | 0.83 | PDGFRA (0.46) | PDGFRACDK5TYRO3KMT2AELANE | |
| SCHEMBL8304178 | 0.79 | ELANE (0.54) | PDGFRACDK5TYRO3GAAELANE | |
| SCHEMBL29139533 | 0.74 | KMT2A (0.42) | PDGFRACDK5TYRO3KMOKMT2A | |
| SCHEMBL5103453 | 0.72 | PDGFRA (0.65) | PDGFRACDK5TYRO3ELANEALOX15 | |
| SCHEMBL8303129 | 0.71 | NOTUM (0.40) | ELANEALDH1A1CYP1A2AKR1B1PTGDR2 | |
| SCHEMBL19532532 | 0.70 | ELANE (0.40) | PDGFRACDK5TYRO3KMOKMT2A | |
| SCHEMBL29139530 | 0.67 | KMT2A (0.49) | KMOKMT2AGAAELANEALDH1A1 | |
| SCHEMBL17423732 | 0.67 | KMO (0.46) | KMOMAT2AKMT2AGAACYP1A2 | |
| SCHEMBL12984735 | 0.67 | KMO (0.52) | KMOMAT2AKDM4CTSPOAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0701555-B1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1999-08-04 | — | — | EP | disclosed |
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |
| EP-0689539-B1 | ANTIPSYCHOTIC INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1997-12-03 | — | — | EP | disclosed |
| US-5665732-A | Indazole derivatives | MERCK, SHARP & DOHME LTD. (GB) | 1997-09-09 | — | — | US | disclosed |
| WO-1994021630-A1 | ANTIPSYCHOTIC INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-29 | — | — | WO | disclosed |