Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 4/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 5/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL829993 | 0.93 | SPPL2A (0.49) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL830368 | 0.91 | SPPL2A (0.48) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14189504 | 0.88 | SPPL2A (0.65) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL830661 | 0.88 | SPPL2A (0.45) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL830059 | 0.86 | SPPL2A (0.44) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL830369 | 0.84 | SPPL2A (0.48) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL830228 | 0.83 | SPPL2A (0.56) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14489586 | 0.81 | SPPL2A (0.55) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14489584 | 0.80 | KMT2A (0.59) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL830321 | 0.80 | SPPL2A (0.48) | SPPL2APSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143421-B2 | Broadspectrum substituted benzimidazole sulfonamide HIV protease inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2012-03-27 | — | — | US | disclosed |
| EP-1485358-B1 | BROADSPECTRUM SUBSTITUTED BENZIMIDAZOLE SULFONAMIDE HIV PROTEASE INHIBITORS | TIBOTEC PHARM LTD (IE) | 2011-02-02 | — | — | EP | disclosed |
| US-20090203743-A1 | SMALL MOLECULE ENTRY INHIBITORS | SURLERAUX DOMINIQUE LOUIS | 2009-08-13 | — | — | US | disclosed |
| US-20050171175-A1 | Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors | TIBOTEC PHARMACEUTICALS LTD (IE) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203743-A1 | SMALL MOLECULE ENTRY INHIBITORS | NR0B1, LTC4S, LTB4R | SPPL2A 2682/4885PSEN1 2725/4885PSEN2 3097/4885 |
| US-20050171175-A1 | Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors | CYP2S1, CYP2C8, PRSS8 | SPPL2A 1494/4885PSEN1 1365/4885PSEN2 1844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.