Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 10/20 | 0.58 |
| ▸ | MMP13 | P45452 | 3/20 | 0.58 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | MMEL1 | Q495T6 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6141808 | 0.89 | MMP12 (0.64) | MMP12MMP13MMEABL1MMEL1 | |
| SCHEMBL8299546 | 0.89 | MMP12 (0.64) | MMP12MMP13MMEABL1MMEL1 | |
| SCHEMBL8300026 | 0.86 | MMP12 (0.66) | MMP12MMP13ABL1MMP3MMP9 | |
| SCHEMBL6882182 | 0.84 | MMP12 (0.57) | MMP12MMP13ABL1EPHX2PPARG | |
| SCHEMBL6368969 | 0.81 | MMP12 (0.70) | MMP12MMP13MMEABL1MMP3 | |
| SCHEMBL8301905 | 0.81 | MMP12 (0.78) | MMP12MMP13ABL1EPHX2PPARG | |
| SCHEMBL8343263 | 0.78 | MMP12 (0.58) | MMP12MMP13ABL1EPHX2PPARG | |
| SCHEMBL6874949 | 0.77 | MMP12 (0.57) | MMP12MMP13ABL1EPHX2PPARG | |
| SCHEMBL6883411 | 0.76 | MMP12 (0.64) | MMP12MMP13MMEABL1MMP3 | |
| SCHEMBL6451093 | 0.76 | MMP12 (0.64) | MMP12MMP13ABL1EPHX2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003115-A1 | THIOPHENE AMINO ACID DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-13 | — | — | WO | disclosed |