Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | CES2 | O00748 | 1/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CDC25B | P30305 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isopropylamine SCHEMBL27585721 | 0.92 | TSHR (0.54) | TSHRCES2BCHECES1ALDH1A1 | |
| SCHEMBL7467330 | 0.91 | TSHR (0.70) | TSHRALDH1A1HSD17B10TDP1TP53 | |
| SCHEMBL23817273 | 0.87 | CES2 (0.49) | TSHRCES2BCHECES1ALDH1A1 | |
| SCHEMBL14992393 | 0.86 | TSHR (0.63) | TSHRALDH1A1HSD17B10TDP1TP53 | |
| SCHEMBL5248806 | 0.86 | TSHR (0.63) | TSHRALDH1A1HSD17B10TDP1TP53 | |
| SCHEMBL2325118 | 0.85 | TSHR (0.74) | TSHRALDH1A1HSD17B10TDP1TP53 | |
| SCHEMBL29604433 | 0.85 | TSHR (0.74) | TSHRALDH1A1HSD17B10TDP1TP53 | |
| SCHEMBL18867935 | 0.85 | TSHR (0.74) | TSHRALDH1A1HSD17B10TDP1TP53 | |
| SCHEMBL1958113 | 0.85 | TSHR (0.57) | TSHRCES2CES1ALDH1A1HSD17B10 | |
| SCHEMBL7728983 | 0.84 | CA12 (0.62) | TSHRALDH1A1HSD17B10TDP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117946303-A | Catalyst, preparation method thereof, method for regulating and controlling ethylene polymerization kinetics behavior and application | 中国石油化工股份有限公司 | 2024-04-30 | — | — | CN | claimed |
| CN-114865080-A | Lithium ion battery electrolyte and lithium ion battery | 香河昆仑新能源材料股份有限公司 | 2022-08-05 | — | — | CN | claimed |
| CN-108794505-A | A kind of preparation method of benzheterocycle | 南京齐正化学有限公司 | 2018-11-13 | — | — | CN | claimed |
| CN-108218668-A | A kind of restoring method of 2,6 difluoro-benzoic acid ethyl esters | 南京齐正化学有限公司 | 2018-06-29 | — | — | CN | claimed |
| CN-102344419-A | Preparation method of broad-spectrum antifungal drug fluconazole | ZHEJIANG GENEBEST PHARMACEUTICAL CO LTD | 2012-02-08 | — | — | CN | claimed |
| CN-117946303-A | Catalyst, preparation method thereof, method for regulating and controlling ethylene polymerization kinetics behavior and application | 中国石油化工股份有限公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-117946304-A | Spherical catalyst component containing fluoroester electron donor, preparation method, catalyst and application thereof in ethylene polymerization | 中国石油化工股份有限公司 | 2024-04-30 | — | — | CN | disclosed |
| US-20230121721-A1 | MONOACYLGLYCEROL LIPASE INHIBITORS | STICHTING HET NEDERLANDS KANKER INST ANTONI VAN LEEUWENHOEK ZIEKENHUIS (NL) | 2023-04-20 | — | — | US | disclosed |
| EP-4114829-A1 | MONOACYLGLYCEROL LIPASE INHIBITORS | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis (NL) | 2023-01-11 | — | — | EP | disclosed |
| CN-114865080-A | Lithium ion battery electrolyte and lithium ion battery | 香河昆仑新能源材料股份有限公司 | 2022-08-05 | — | — | CN | disclosed |
| EP-3875452-A1 | MONOACYLGLYCEROL LIPASE INHIBITORS | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis (NL) | 2021-09-08 | — | — | EP | disclosed |
| CN-110167926-A | POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS | 米托布里奇公司 | 2019-08-23 | — | — | CN | disclosed |
| CN-1137884-C | Indazole compounds and pharmaceutical compositions that inhibit protein kinases and methods of use thereof | ������ҩ������˾ | 2004-02-11 | — | — | CN | disclosed |
| CN-1425008-A | 3-aminoquinazolin-2, 4-dione antibacterial agents | WARNER LAMBERT CO (US) | 2003-06-18 | — | — | CN | disclosed |
| US-6534524-B1 | Antiproliferative agents, including axitinib | AGOURON PHARMACEUTICALS, INC. | 2003-03-18 | — | — | US | disclosed |
| US-6531491-B1 | Methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, | AGOURON PHARAMACEUTICALS, INC. | 2003-03-11 | — | — | US | disclosed |
| CN-1374950-A | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases and their use | AGOURON PHARMACETUICALS INC (US) | 2002-10-16 | — | — | CN | disclosed |
| EP-1218348-A2 | INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE | AGOURON PHARMACEUTICALS, INC. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001002369-A2 | INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE | AGOURON PHARMACEUTICALS, INC. (US) | 2001-01-11 | — | — | WO | disclosed |
| CN-1137271-A | 4-benzoylisoxazoles and their use as herbicides | RHONE POULENC AGRICULTURE (GB) | 1996-12-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230121721-A1 | MONOACYLGLYCEROL LIPASE INHIBITORS | MGLL, PNLIP, LIPA | TSHR 4078/4885CES2 64/4885BCHE 311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.