Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8291693 | 0.88 | CNR2 (0.37) | MTNR1AMTNR1BAKR1C3KDM4EALDH1A1 | |
| SCHEMBL7962276 | 0.80 | AKR1C3 (0.41) | MTNR1AMTNR1BAKR1C3KDM4EALDH1A1 | |
| SCHEMBL2156670 | 0.78 | AKR1C3 (0.48) | AKR1C3ALDH1A1HSD17B10NR1I2SMN1; SMN2 | |
| SCHEMBL24254051 | 0.77 | ALDH1A1 (0.46) | ALDH1A1HSD17B10NR1I2SMN1; SMN2MAPT | |
| SCHEMBL8762255 | 0.71 | TAS1R3 (0.44) | KDM4EALDH1A1HPGDHSD17B10NR1I2 | |
| SCHEMBL3225589 | 0.71 | NR1I2 (0.41) | ALDH1A1HSD17B10NR1I2 | |
| SCHEMBL8761832 | 0.70 | TAS1R3 (0.43) | KDM4EALDH1A1HPGDHSD17B10L3MBTL1 | |
| SCHEMBL8502442 | 0.70 | MAPT (0.46) | MTNR1AMTNR1BKDM4EALDH1A1NR1I2 | |
| SCHEMBL5241843 | 0.70 | AKR1C3 (0.48) | MTNR1AMTNR1BAKR1C3KDM4EALDH1A1 | |
| SCHEMBL8085605 | 0.69 | ALDH1A1 (0.42) | MTNR1AMTNR1BALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620214-B1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | LILLY CO ELI (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5578634-A | SEPTIC SHOCK TREATMENT | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0620214-A1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |