Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 14/20 | 0.71 |
| ▸ | GFER | P55789 | 1/20 | 0.64 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.60 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | THRA | P10827 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14979163 | 0.90 | PLA2G2A (0.62) | PLA2G2AGFERPTGDR2PLA2G1BALDH1A1 | |
| SCHEMBL8300494 | 0.88 | PLA2G2A (0.66) | PLA2G2AGFERPTGDR2PLA2G1BALDH1A1 | |
| SCHEMBL7961998 | 0.88 | PLA2G2A (0.62) | PLA2G2APLA2G1BALDH1A1GAAMAPT | |
| SCHEMBL8292072 | 0.87 | PLA2G2A (0.61) | PLA2G2APLA2G1BALDH1A1GAAMAPT | |
| SCHEMBL7961660 | 0.87 | PLA2G2A (0.75) | PLA2G2APLA2G1BALDH1A1GAAMAPT | |
| SCHEMBL14979166 | 0.86 | LMNA (0.59) | PLA2G2AGFERPTGDR2PLA2G1BMAPT | |
| SCHEMBL8645997 | 0.86 | PLA2G2A (0.83) | PLA2G2APLA2G1BALDH1A1MAPTPKM | |
| SCHEMBL29941473 | 0.84 | PLA2G2A (0.75) | PLA2G2AGFERPTGDR2ALDH1A1KDM4E | |
| SCHEMBL8292077 | 0.83 | PLA2G2A (1.00) | PLA2G2AGFERPTGDR2 | |
| SCHEMBL8291607 | 0.83 | PLA2G2A (0.68) | PLA2G2APLA2G1BALDH1A1MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620214-B1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | LILLY CO ELI (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5578634-A | SEPTIC SHOCK TREATMENT | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0620214-A1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |