Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.55 |
| ▸ | PRKCB | P05771 | 13/20 | 0.55 |
| ▸ | PRKCA | P17252 | 13/20 | 0.55 |
| ▸ | PRKCG | P05129 | 12/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.55 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.55 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14032411 | 0.90 | GSK3B (0.43) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL8300692 | 0.88 | GSK3B (0.47) | GSK3BPRKCBPRKCAPRKCG | |
| SCHEMBL8302978 | 0.83 | GSK3B (0.59) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL14032339 | 0.83 | CAMK2D (0.39) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL14050970 | 0.82 | GSK3B (0.43) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL1127953 | 0.81 | GSK3B (0.68) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5754128 | 0.80 | PRKCA (0.85) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5756894 | 0.74 | GSK3B (0.76) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL13013365 | 0.74 | GSK3B (0.73) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL3771437 | 0.74 | PRKCA (0.84) | GSK3BPRKCBPRKCAPRKCGKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654255-B1 | SUBSTITUTED INDAZOLYL(INDOLYL)MALEIMIDE DERIVATIVES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-27 | — | — | EP | disclosed |
| WO-2005000836-A1 | SUBSTITUTED INDAZOLYL(INDOLYL)MALEIMIDE DERIVATIVES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-01-06 | — | — | WO | disclosed |