Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 5/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.42 |
| ▸ | FPR1 | P21462 | 3/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8297509 | 0.81 | FPR2 (0.42) | FPR2HDAC6HDAC1HDAC8FPR1 | |
| SCHEMBL8863137 | 0.80 | FPR2 (0.45) | FPR2HDAC6HDAC1HDAC8FPR1 | |
| SCHEMBL8668113 | 0.75 | FPR2 (0.41) | FPR2HDAC6HDAC1HDAC8FPR1 | |
| SCHEMBL6361911 | 0.72 | HDAC1 (0.47) | FPR2HDAC6HDAC1HDAC8FPR1 | |
| SCHEMBL5566079 | 0.69 | MMP1 (0.44) | FPR2HDAC6HDAC1HDAC8FPR1 | |
| SCHEMBL5566073 | 0.69 | MMP1 (0.44) | FPR2HDAC6HDAC1HDAC8FPR1 | |
| SCHEMBL16493351 | 0.68 | FPR2 (0.56) | FPR2HDAC6HDAC1HDAC8FPR1 | |
| SCHEMBL7414726 | 0.68 | FPR2 (0.54) | FPR2HDAC6HDAC1HDAC8FPR1 | |
| SCHEMBL7414725 | 0.68 | FPR2 (0.54) | FPR2HDAC6HDAC1HDAC8FPR1 | |
| SCHEMBL7933692 | 0.68 | FPR2 (0.54) | FPR2HDAC6HDAC1HDAC8FPR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004110434-A1 | 2-PYRROLIDONE DERIVATIVES AND USE THEREOF AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |