Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8300493 | 0.77 | ALDH1A1 (0.39) | LMNAALDH1A1TDP1MAPK1 | |
| SCHEMBL8434188 | 0.76 | L3MBTL1 (0.38) | LMNAALDH1A1L3MBTL1HPGDATM | |
| Acetic Acid SCHEMBL8306059 | 0.73 | L3MBTL1 (0.32) | LMNAALDH1A1L3MBTL1HPGDATM | |
| SCHEMBL14389910 | 0.70 | LMNA (0.46) | LMNAHSD17B10ALDH1A1TSHRKDM4E | |
| Acetic Acid SCHEMBL8306061 | 0.70 | L3MBTL1 (0.34) | ALDH1A1L3MBTL1HPGDATMKDM4E | |
| SCHEMBL27492109 | 0.69 | GAA (0.54) | LMNAHSD17B10ALDH1A1L3MBTL1TSHR | |
| SCHEMBL11037027 | 0.68 | ALDH1A1 (0.42) | LMNAALDH1A1L3MBTL1HPGDATM | |
| SCHEMBL8301307 | 0.68 | HSD17B10 (0.39) | LMNAHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL17918582 | 0.67 | KMT2A (0.45) | HSD17B10L3MBTL1TSHRTDP1KDM4E | |
| SCHEMBL5935768 | 0.65 | GAA (0.51) | LMNAHSD17B10ALDH1A1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944621-A1 | 2-IMIDAZOLINYLAMINOINDOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023610-A1 | 2-IMIDAZOLINYLAMINOINDOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1998-06-04 | — | — | WO | disclosed |