Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 19/20 | 0.57 |
| ▸ | TACR2 | P21452 | 4/20 | 0.57 |
| ▸ | TACR3 | P29371 | 4/20 | 0.57 |
| ▸ | CCR5 | P51681 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203185 | 0.88 | TACR1 (0.68) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL8292835 | 0.87 | TACR1 (0.56) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL8300343 | 0.85 | TACR1 (0.75) | TACR1TACR2TACR3CCR5 | |
| Hydrochloric Acid SCHEMBL8742817 | 0.84 | TACR1 (0.74) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL8589071 | 0.82 | TACR1 (0.52) | TACR1TACR2TACR3 | |
| SCHEMBL8483945 | 0.80 | TACR1 (0.55) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL7817576 | 0.79 | TACR1 (0.82) | TACR1TACR2 | |
| SCHEMBL7847578 | 0.76 | TACR1 (0.61) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL8352523 | 0.75 | CCR5 (0.45) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL8292833 | 0.74 | TACR1 (0.43) | TACR1TACR2TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512901-B1 | Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1999-06-23 | — | — | EP | disclosed |
| US-5770735-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1998-06-23 | — | — | US | disclosed |
| US-5625060-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present | Sanofi, Elf (FR) | 1997-04-29 | — | — | US | disclosed |
| US-5340822-A | Substance P, neurokinin antagonists | ELF SANOFI (FR) | 1994-08-23 | — | — | US | disclosed |
| EP-0512901-A1 | Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-11-11 | — | — | EP | disclosed |