Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 2/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GGT1 | P19440 | 1/20 | 0.44 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273868 | 0.85 | SMN1; SMN2 (0.45) | CHRNB2CHRNB4CHRNA3CHRNA4ACE | |
| SCHEMBL8302557 | 0.83 | TLR2 (0.41) | TLR2CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL27458051 | 0.81 | ACE (0.58) | TLR2ACESMN1; SMN2ABCB11LMNA | |
| SCHEMBL6237696 | 0.81 | ACE (0.58) | TLR2ACESMN1; SMN2ABCB11LMNA | |
| SCHEMBL6240311 | 0.81 | ACE (0.58) | TLR2ACESMN1; SMN2ABCB11LMNA | |
| Hydrochloric Acid SCHEMBL11206033 | 0.81 | SMN1; SMN2 (0.50) | ACESMN1; SMN2MMP8ABCB11LMNA | |
| Bromide SCHEMBL11083780 | 0.80 | ALOX5 (0.49) | GGT1SIRT2SIRT1 | |
| SCHEMBL14265369 | 0.80 | SMN1; SMN2 (0.55) | ACESMN1; SMN2MMP8ABCB11LMNA | |
| SCHEMBL10482405 | 0.80 | SMN1; SMN2 (0.55) | ACESMN1; SMN2MMP8ABCB11LMNA | |
| Water SCHEMBL28202314 | 0.80 | TLR2 (0.59) | TLR2SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635816-B1 | ENALAPRIL-NITROXYDERIVATIVES DERIVATIVES AND RELATED COMPOUNDS AS ACE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | NICOX SA (FR) | 2009-03-04 | — | — | EP | disclosed |
| WO-2004110432-A1 | ENALAPRIL-NITROXYDERIVATIVES DERIVATIVES AND RELATED COMPOUNDS AS ACE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | NICOX S.A. (FR) | 2004-12-23 | — | — | WO | disclosed |