Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 3/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | GGT1 | P19440 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8301017 | 0.83 | TLR2 (0.51) | TLR2CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL14135315 | 0.76 | CTSK (0.43) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8298925 | 0.74 | ACE (0.63) | LMNA | |
| SCHEMBL8580276 | 0.74 | CHRNB2 (0.44) | ITGB3ITGA2BCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL8298922 | 0.73 | ACE (0.64) | LMNA | |
| SCHEMBL7270118 | 0.71 | CTSK (0.46) | — | |
| SCHEMBL13416429 | 0.70 | CTSK (0.64) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7273868 | 0.70 | SMN1; SMN2 (0.45) | CHRNB2CHRNB4CHRNA3CHRNA4GGT1 | |
| SCHEMBL13929816 | 0.69 | ACE (0.41) | LMNA | |
| SCHEMBL18806214 | 0.69 | GGT1 (0.67) | TLR2GGT1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004110432-A1 | ENALAPRIL-NITROXYDERIVATIVES DERIVATIVES AND RELATED COMPOUNDS AS ACE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | NICOX S.A. (FR) | 2004-12-23 | — | — | WO | disclosed |