Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.53 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 4/20 | 0.46 |
| ▸ | LY6K | Q17RY6 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | ESRRA | P11474 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8301094 | 0.82 | PARP14 (0.46) | RAD52NCOA3BRD4PTGS1KDR | |
| SCHEMBL7222256 | 0.78 | BRD4 (0.47) | RAD52NCOA3BRD4CYP17A1KDR | |
| SCHEMBL7220116 | 0.77 | BCL2L1 (0.48) | BRD4KDRAURKAAURKBESRRA | |
| SCHEMBL7221513 | 0.76 | BRD4 (0.45) | RAD52NCOA3BRD4KDRAURKA | |
| SCHEMBL7226423 | 0.76 | MRGPRX1 (0.45) | RAD52NCOA3BRD4KDRAURKA | |
| SCHEMBL8307237 | 0.76 | AR (0.56) | BRD4KDRAURKAAURKBMRGPRX1 | |
| SCHEMBL7222716 | 0.76 | MRGPRX1 (0.54) | RAD52NCOA3BRD4PTGS1KDR | |
| SCHEMBL7467297 | 0.73 | HPGD (0.43) | RAD52NCOA3BRD4CYP17A1KDR | |
| SCHEMBL7228204 | 0.69 | PGR (0.51) | CYP17A1BRAF | |
| SCHEMBL7219476 | 0.69 | MRGPRX1 (0.52) | MRGPRX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966436-A1 | ARYL SULFONAMIDES AND ANALOGUES THEREOF AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | Bayer Aktiengesellschaft (DE) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998037061-A1 | ARYL SULFONAMIDES AND ANALOGUES THEREOF AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-08-27 | — | — | WO | disclosed |