Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP14 | Q460N5 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 4/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8301095 | 0.82 | RAD52 (0.53) | PARP14PTGS1MRGPRX1RAD52NCOA3 | |
| SCHEMBL8307237 | 0.72 | AR (0.56) | LMNAMRGPRX1MEN1MAPTHPGD | |
| SCHEMBL7222716 | 0.71 | MRGPRX1 (0.54) | PARP14PTGS1LMNAMRGPRX1MEN1 | |
| SCHEMBL10078555 | 0.70 | KEAP1 (0.55) | PARP14KDM4EKMT2AKEAP1BRD4 | |
| SCHEMBL29901800 | 0.70 | KEAP1 (0.55) | PARP14KDM4EKMT2AKEAP1BRD4 | |
| SCHEMBL2128507 | 0.70 | KEAP1 (0.68) | PARP14ALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL7219476 | 0.69 | MRGPRX1 (0.52) | MRGPRX1 | |
| SCHEMBL3726856 | 0.69 | HTR1B (0.47) | PTGS1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL7222256 | 0.69 | BRD4 (0.47) | ALDH1A1LMNAMRGPRX1KDM4EHPGD | |
| SCHEMBL30673310 | 0.69 | PTGS1 (0.47) | PARP14PTGS1ALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966436-A1 | ARYL SULFONAMIDES AND ANALOGUES THEREOF AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | Bayer Aktiengesellschaft (DE) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998037061-A1 | ARYL SULFONAMIDES AND ANALOGUES THEREOF AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-08-27 | — | — | WO | disclosed |