⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9164495 | 0.88 | — | — | |
| SCHEMBL8932159 | 0.84 | TDP1 (0.30) | — | |
| SCHEMBL6208851 | 0.82 | GABRA1 (0.36) | — | |
| SCHEMBL6647064 | 0.81 | — | — | |
| SCHEMBL3232243 | 0.79 | GABRA1 (0.45) | — | |
| SCHEMBL28438124 | 0.79 | — | — | |
| SCHEMBL3059394 | 0.77 | GABRA1 (0.41) | — | |
| SCHEMBL7857695 | 0.77 | — | — | |
| SCHEMBL28415052 | 0.76 | NR1I2 (0.33) | — | |
| SCHEMBL11567441 | 0.74 | ALDH1A1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841922-A4 | 1H-4(5)-SUBSTITUTED IMIDAZOLE DERIVATIVES | GLIATECH INC (US) | 1999-03-10 | — | — | EP | disclosed |
| EP-0841922-A1 | 1H-4(5)-SUBSTITUTED IMIDAZOLE DERIVATIVES | GLIATECH, INC. (US) | 1998-05-20 | — | — | EP | disclosed |
| WO-1996038142-A1 | 1H-4(5)-SUBSTITUTED IMIDAZOLE DERIVATIVES | GLIATECH, INC. (US) | 1996-12-05 | — | — | WO | disclosed |