Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.72 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CNR2 | P34972 | 3/20 | 0.53 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.52 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7882170 | 0.87 | MTNR1A (0.67) | MTNR1AMTNR1BKDM4ECRHBPCRHR2 | |
| SCHEMBL29937110 | 0.86 | MTNR1A (0.65) | MTNR1AMTNR1BKDM4ECRHBPCRHR2 | |
| SCHEMBL1422759 | 0.86 | MTNR1A (0.65) | MTNR1AMTNR1BKDM4ECRHBPCRHR2 | |
| SCHEMBL29937398 | 0.86 | MTNR1A (0.65) | MTNR1AMTNR1BKDM4ECRHBPCRHR2 | |
| SCHEMBL7882180 | 0.85 | KDM4E (0.78) | MTNR1AMTNR1BKDM4ECRHBPCRHR2 | |
| SCHEMBL7882288 | 0.85 | MTNR1A (0.64) | MTNR1AMTNR1BKDM4ECRHBPCRHR2 | |
| SCHEMBL11211402 | 0.85 | ALDH1A1 (0.71) | MTNR1AMTNR1BKDM4ECRHBPCRHR2 | |
| SCHEMBL30403537 | 0.84 | MTNR1A (0.62) | MTNR1AMTNR1BKDM4ECRHBPCRHR2 | |
| SCHEMBL7880746 | 0.83 | MTNR1A (0.62) | MTNR1AMTNR1BKDM4ECRHBPCRHR2 | |
| SCHEMBL700800 | 0.83 | ALDH1A1 (0.69) | MTNR1AMTNR1BKDM4ECRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0553218-B1 | INDOLE DERIVATIVES | RECKITT & COLMANN PROD LTD (GB) | 1999-06-16 | — | — | EP | disclosed |
| EP-0553218-A1 | INDOLE DERIVATIVES | RECKITT & COLMAN PRODUCTS LIMITED (GB) | 1993-08-04 | — | — | EP | disclosed |
| WO-1992006972-A1 | INDOLE DERIVATIVES | RECKITT & COLMAN PRODUCTS LIMITED (GB) | 1992-04-30 | — | — | WO | disclosed |