SCHEMBL8301494

SCHEMBL8301494

CC(N)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(C#N)nc1

nearest known ligand 0.48

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
F2 P00734 12/20 0.48
PKM P14618 2/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
F11 P03951 3/20 0.44
ALDH1A1 P00352 2/20 0.43
NAMPT P43490 1/20 0.43
NPC1 O15118 1/20 0.43
DPP4 P27487 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6483096 0.85 F2 (0.53) F2PKMCYP3A4CYP2C9CYP2C19
Acetic Acid SCHEMBL6484260 0.84 F2 (0.50) F2PKMCYP3A4CYP2C9CYP2C19
SCHEMBL6476709 0.82 ALDH1A1 (0.47) F2PKMCYP3A4CYP2C9CYP2C19
SCHEMBL21429847 0.80 F2 (0.59) F2PKMCYP3A4CYP2C9CYP2C19
SCHEMBL6477306 0.79 ALDH1A1 (0.48) F2PKMCYP3A4CYP2C9CYP2C19
SCHEMBL6487152 0.78 NAMPT (0.48) PKMCYP3A4CYP2C9CYP2C19ALDH1A1
SCHEMBL7050813 0.78 F2 (0.52) F2
SCHEMBL15386497 0.78 F2 (0.56) F2PKMCYP3A4CYP2C9CYP2C19
SCHEMBL12658507 0.78 F2 (0.56) F2PKMCYP3A4CYP2C9CYP2C19
SCHEMBL7456140 0.75 F2 (0.53) F2PKMCYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0931069-A1 PROCESS FOR PREPARING AMIDINES BASF AKTIENGESELLSCHAFT (DE) 1999-07-28 EP disclosed
WO-1998009950-A1 PROCESS FOR PREPARING AMIDINES BASF AKTIENGESELLSCHAFT (DE) 1998-03-12 WO disclosed