SCHEMBL8301680

SCHEMBL8301680

CSc1cc(C(F)(F)F)ccc1I

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.37
PDE2A O00408 3/20 0.37
ADRA2A P08913 1/20 0.37
ADRA2B P18089 1/20 0.37
ADRA2C P18825 1/20 0.37
ADRA1D P25100 1/20 0.37
ADRA1A P35348 1/20 0.37
ADRA1B P35368 1/20 0.37
PTPN5 P54829 1/20 0.34
NOTUM Q6P988 1/20 0.34
KIF11 P52732 3/20 0.34
KDM4E B2RXH2 2/20 0.34
NPSR1 Q6W5P4 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
GABRP O00591 1/20 0.34
GABRD O14764 1/20 0.34
GABRA1 P14867 1/20 0.34
GABRB1 P18505 1/20 0.34
GABRG2 P18507 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5356207 0.85 ALDH1A1 (0.30) ALDH1A1
SCHEMBL28230730 0.81 ADRA2A (0.42) ALDH1A1PDE2AADRA2AADRA2BADRA2C
SCHEMBL16140866 0.79 DDR1 (0.38) ALDH1A1PDE2AADRA2CADRA1ANPSR1
SCHEMBL1988105 0.78 ADRA2A (0.40) ALDH1A1PDE2AADRA2AADRA2BADRA2C
SCHEMBL27373627 0.78 CES2 (0.46) ALDH1A1PDE2AADRA2AADRA2BADRA2C
SCHEMBL18885104 0.78 PDE2A (0.42) ALDH1A1PDE2AADRA2AADRA2BADRA2C
SCHEMBL8109502 0.76 ADRA2A (0.40) ALDH1A1PDE2AADRA2AADRA2BADRA2C
SCHEMBL6785112 0.76 MEN1 (0.44) ALDH1A1PDE2AADRA2AADRA2BADRA2C
SCHEMBL31365812 0.76 ADRA2A (0.40) ALDH1A1PDE2AADRA2AADRA2BADRA2C
SCHEMBL20156027 0.76 MAPT (0.44) ALDH1A1ADRA2AADRA2BADRA2CADRA1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5998334-A Pyrazole compounds, processes for their production and herbicides containing them ISHIHARA SANGYO KAISHA LTD. (JP) 1999-12-07 US disclosed
EP-0900205-A1 PYRAZOLE COMPOUNDS, PROCESSES FOR THEIR PRODUCTION AND HERBICIDES CONTAINING THEM ISHIHARA SANGYO KAISHA, LTD. (JP) 1999-03-10 EP disclosed
WO-1997041106-A1 PYRAZOLE COMPOUNDS, PROCESSES FOR THEIR PRODUCTION AND HERBICIDES CONTAINING THEM ISHIHARA SANGYO KAISHA LTD. (JP) 1997-11-06 WO disclosed