Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | OGT | O15294 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439768 | 0.91 | KCNH2 (0.54) | KCNH2GRIN2BHTR1ADRD2HTR2A | |
| SCHEMBL8301786 | 0.90 | HTR1A (0.53) | KCNH2GRIN2BHTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL8542941 | 0.84 | MEN1 (0.56) | KCNH2GRIN2BALDH1A1ATMLMNA | |
| SCHEMBL466863 | 0.81 | GRIN2B (0.61) | KCNH2GRIN2BHTR1ADRD2HTR2A | |
| SCHEMBL9562497 | 0.80 | KCNH2 (0.57) | KCNH2GRIN2BHTR1ADRD2HTR2A | |
| SCHEMBL9562478 | 0.80 | GRIN2B (0.60) | KCNH2GRIN2BHTR1ADRD2HTR2A | |
| SCHEMBL9562529 | 0.80 | KCNH2 (0.57) | KCNH2GRIN2BHTR2ATSHRTP53 | |
| SCHEMBL9562489 | 0.80 | KCNH2 (0.51) | KCNH2GRIN2BHTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL8548193 | 0.80 | GRIN2B (0.55) | KCNH2GRIN2BALDH1A1ATMOGT | |
| Hydrochloric Acid SCHEMBL8548360 | 0.80 | GRIN2B (0.55) | KCNH2GRIN2BALDH1A1ATMOGT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848707-B1 | 4-(CYCLOALKYL)PIPERIDINES AND 4-(CYCLOALKYLALKYL)-PIPERIDINES DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL APPLICATIONS THEREOF | SYNTHELABO (FR) | 1999-08-04 | — | — | EP | disclosed |