Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8301971 | 0.90 | KCNH2 (0.52) | HTR1ADRD2HTR2AGRIN2BKCNH2 | |
| SCHEMBL8439768 | 0.87 | KCNH2 (0.54) | HTR1ADRD2HTR2AGRIN2BKCNH2 | |
| SCHEMBL9768368 | 0.82 | GRIN2B (0.60) | HTR1ADRD2HTR2AGRIN2BKCNH2 | |
| SCHEMBL9768289 | 0.78 | GRIN2B (0.57) | HTR1ADRD2HTR2AGRIN2BKCNH2 | |
| SCHEMBL8302305 | 0.77 | GRIN2B (0.52) | HTR1ADRD2HTR2AGRIN2BEPHX2 | |
| SCHEMBL8300540 | 0.77 | HTR1A (0.56) | HTR1ADRD2HTR2AEPHX2GAA | |
| SCHEMBL466863 | 0.77 | GRIN2B (0.61) | HTR1ADRD2HTR2AGRIN2BKCNH2 | |
| SCHEMBL9562478 | 0.75 | GRIN2B (0.60) | HTR1ADRD2HTR2AGRIN2BKCNH2 | |
| SCHEMBL9562529 | 0.75 | KCNH2 (0.57) | HTR2AGRIN2BKCNH2GRIN1 | |
| SCHEMBL9562497 | 0.75 | KCNH2 (0.57) | HTR1ADRD2HTR2AGRIN2BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848707-B1 | 4-(CYCLOALKYL)PIPERIDINES AND 4-(CYCLOALKYLALKYL)-PIPERIDINES DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL APPLICATIONS THEREOF | SYNTHELABO (FR) | 1999-08-04 | — | — | EP | disclosed |