Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | REN | P00797 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | RORC | P51449 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.51 |
| ▸ | BRD4 | O60885 | 3/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.49 |
| ▸ | NQO2 | P16083 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1770605 | 0.93 | MTNR1A (0.55) | HDAC1HDAC6MTNR1AMTNR1BNQO2 | |
| SCHEMBL10564578 | 0.84 | CYP3A4 (0.57) | HDAC1HDAC6RENCYP3A4RORC | |
| SCHEMBL6719684 | 0.84 | TRPV1 (0.61) | RENCYP3A4RORCTRPV1MTNR1A | |
| SCHEMBL6728768 | 0.84 | TRPV1 (0.49) | RENCYP3A4TRPV1MTNR1AMTNR1B | |
| SCHEMBL1770902 | 0.81 | MTNR1A (0.55) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL6719487 | 0.81 | HDAC1 (0.53) | HDAC1HDAC6RORCCREBBPBRD4 | |
| SCHEMBL10559940 | 0.80 | ALDH1A1 (0.58) | CYP3A4TRPV1MTNR1A | |
| SCHEMBL8606442 | 0.80 | HDAC1 (0.53) | HDAC1HDAC6RENRORCCREBBP | |
| SCHEMBL10092656 | 0.79 | MEN1 (0.57) | HDAC1HDAC6RORCCREBBPBRD4 | |
| SCHEMBL1771178 | 0.79 | MTNR1A (0.54) | TRPV1MTNR1AMTNR1BNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004089915-A1 | PIPERAZINE DERIVATIVE RENIN INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | disclosed |