Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.61 |
| ▸ | REN | P00797 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10564578 | 0.87 | CYP3A4 (0.57) | TRPV1RENCYP3A4CHRM2CHRM4 | |
| SCHEMBL8302626 | 0.84 | HDAC1 (0.54) | TRPV1RENCYP3A4MTNR1ARORC | |
| SCHEMBL10559940 | 0.83 | ALDH1A1 (0.58) | TRPV1CYP3A4CHRM2CHRM4MTNR1A | |
| SCHEMBL6728768 | 0.80 | TRPV1 (0.49) | TRPV1RENCYP3A4MTNR1AALDH1A1 | |
| SCHEMBL6717277 | 0.80 | CHRM2 (0.56) | TRPV1RENCYP3A4CHRM2CHRM4 | |
| SCHEMBL6721571 | 0.80 | REN (0.57) | TRPV1RENCYP3A4CHRM2CHRM4 | |
| SCHEMBL12598196 | 0.79 | MTNR1A (0.53) | TRPV1RENCYP3A4MTNR1AALDH1A1 | |
| SCHEMBL6713047 | 0.79 | CYP3A4 (0.48) | TRPV1RENCYP3A4CHRM2CHRM4 | |
| SCHEMBL6721735 | 0.77 | MTNR1A (0.46) | TRPV1RENCYP3A4CHRM2CHRM4 | |
| SCHEMBL4503966 | 0.76 | CHRM2 (0.58) | TRPV1CHRM2CHRM4ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040214832-A1 | Piperazine derivative renin inhibitors | WARNER-LAMBERT COMPANY LLC | 2004-10-28 | — | — | US | disclosed |
| WO-2004089915-A1 | PIPERAZINE DERIVATIVE RENIN INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214832-A1 | Piperazine derivative renin inhibitors | REN, ACE, AGTR2 | TRPV1 2008/4885REN 1/4885CYP3A4 1308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.