Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 9/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 10/20 | 0.41 |
| ▸ | HTR1A | P08908 | 9/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11996935 | 0.74 | PARP1 (0.47) | PARP1DRD2DRD3HTR2AHTR1A | |
| SCHEMBL8446873 | 0.74 | DRD2 (0.45) | PARP1DRD2DRD3HTR2AHTR1A | |
| SCHEMBL9759749 | 0.73 | PARP1 (0.46) | PARP1DRD2DRD3HTR2AHTR1A | |
| SCHEMBL1545365 | 0.72 | PARP1 (0.54) | PARP1DRD2DRD3HTR2AHTR1A | |
| SCHEMBL10416288 | 0.72 | PARP1 (0.54) | PARP1DRD2DRD3HTR2AHTR1A | |
| SCHEMBL8447007 | 0.72 | PARP1 (0.36) | PARP1DRD2DRD3 | |
| SCHEMBL8302484 | 0.72 | PARP1 (0.47) | PARP1DRD2DRD3HTR2AHTR1A | |
| Hydrochloric Acid SCHEMBL9778353 | 0.71 | PARP1 (0.53) | PARP1DRD2DRD3HTR2AHTR1A | |
| SCHEMBL9778374 | 0.70 | ABCB1 (0.60) | PARP1DRD2DRD3HTR2AHTR1A | |
| SCHEMBL1545624 | 0.70 | PARP1 (0.52) | PARP1DRD2DRD3HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4226979-A | — | — | None | — | — | JP | disclosed |
| EP-0458234-B1 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1999-03-31 | — | — | EP | disclosed |
| EP-0458234-B1 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1999-03-31 | — | — | EP | disclosed |
| EP-0458234-A3 | 3-(1,THIAZOLIDINYLBUTYL-4-PIPERAZINYL)-1H-INDAZOLES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | — | 1992-09-30 | — | — | EP | disclosed |
| JP-H04226979-A | 3-(1-THIAZOLIDINYLBUTYL-4-PIPERAZINYL)-1H-INDAZOLE | HOECHST ROUSSEL PHARMACEUT INC | 1992-08-17 | — | — | JP | disclosed |
| EP-0458234-A2 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-11-27 | — | — | EP | disclosed |
| EP-0458234-A2 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-11-27 | — | — | EP | disclosed |
| EP-0458234-A2 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-11-27 | — | — | EP | disclosed |
| US-5041445-A | Antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-08-20 | — | — | US | disclosed |
| US-5041445-A | Antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-08-20 | — | — | US | disclosed |