Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9759749 | 0.82 | PARP1 (0.46) | PARP1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL8302001 | 0.78 | PARP1 (0.48) | PARP1DRD2DRD3 | |
| SCHEMBL9760169 | 0.77 | HTR2A (0.52) | PARP1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL8446873 | 0.75 | DRD2 (0.45) | PARP1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL8302387 | 0.75 | PARP1 (0.47) | PARP1 | |
| SCHEMBL8306648 | 0.75 | DRD4 (0.54) | PARP1HTR2A | |
| SCHEMBL8301654 | 0.74 | PARP1 (0.46) | PARP1 | |
| SCHEMBL1545365 | 0.72 | PARP1 (0.54) | PARP1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL10416288 | 0.72 | PARP1 (0.54) | PARP1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL8302667 | 0.72 | PARP1 (0.43) | PARP1DRD2DRD3HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458234-B1 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1999-03-31 | — | — | EP | disclosed |
| EP-0458234-A2 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-11-27 | — | — | EP | disclosed |